ea0038p365 | Reproduction | SFEBES2015
Murray Alison A
, Armstrong Gregory M
, Murgai Reena
, Gray-Renfrew Alexandra E
, Vere Rebecca E A
, Chapman Karen E
, Critchley Hilary O D
Introduction: Heavy menstrual bleeding (HMB) affects over 1 million women in the UK. At menses, progesterone (P4) withdrawal drives inflammation, tissue break-down and repair of the endometrium. Glucocorticoids are mediators of inflammation and angiogenesis. Our previous studies have demonstrated that differential endometrial expression of the glucocorticoid-metabolising enzymes, 11β-HSD-1 and -2, may play a role in HMB. We hypothesise that aberrant lo...